Um capítulo esquecido na história da psicologia? sexualidades desviantes, psicopatologia e normalidade / A forgotten chapter in the history of psychology? deviant sexualities, psychopathology, and normality / ¿Un capítulo olvidado en la historia de la psicología? sexualidades desviadas, psicopatología y normalidad

Este artigo tem como objetivo produzir uma análise histórica sobre as intersecções entre Psicologia e sexualidade desviantes da norma no Brasil, de fins do século XIX a meados da década de 1980. Esta temporalidade foi escolhida por abarcar o surgimento das pesquisas científicas sobre sexualidade e desvios sexuais, a consolidação dos estudos psicológicos sobre a temática e o processo mais recente de despatologização da homossexualidade. Em termos teóricos e metodológicos, foram adotados os pressupostos da História Social da Psicologia e da historiografia das homossexualidades no Brasil. Desse modo, buscou-se compreender como as ideias, concepções e práticas psicológicas foram mudando ao longo do tempo, em conexão com as transformações socioculturais e políticas que ocorreram durante o século XX. Para isto, foram utilizadas fontes primárias e secundárias de pesquisa com vistas à produção de interpretações sobre as conexões entre as ideias, os atores e os eventos narrados. Argumenta-se, ao longo do artigo, que as ideias e práticas psicológicas estão intrinsecamente conectadas aos contextos socioculturais e políticos de seu tempo, sendo os movimentos dinâmicos e os conflitos presentes nesses contextos fatores determinantes para a sua constituição.(AU)

This article aims to produce a historical analysis of the intersections between Psychology and sexualities that deviate from the norm in Brazil, from the late 19th century to the mid-1980s. This period was chosen because it encompasses the emergence of scientific research on sexuality and sexual deviations, the consolidation of psychological studies on the subject and the most recent process of de-pathologization of homosexuality. Theoretically and methodologically, the assumptions of the Social History of Psychology and the historiography of homosexualities in Brazil were adopted. Therefore, we sought to understand how psychological ideas, conceptions and practices have changed over time, in connection with the sociocultural and political transformations that occurred throughout the 20th century. For this, primary and secondary sources of research were used to produce interpretations about the connections between the ideas, the actors and the narrated events. It is argued, throughout the article, that the psychological ideas and practices are intrinsically connected to the sociocultural and political contexts of their time, being the dynamic movements and conflicts present in these contexts determining factors for their constitution.(AU)

Este artículo tiene como objetivo realizar un análisis histórico de las intersecciones entre la Psicología y las sexualidades desviadas de la norma en Brasil desde finales del siglo XIX hasta mediados de la década de 1980. Esta temporalidad fue elegida por abarcar el surgimiento de las investigaciones científicas sobre sexualidad y desvíos sexuales, la consolidación de los estudios psicológicos sobre el tema y el más reciente proceso de despatologización de la homosexualidad. En el marco teórico y metodológico, se adoptaron los presupuestos de la Historia Social de la Psicología y de la historiografía de las homosexualidades en Brasil. De esta manera, se pretende comprender cómo las ideas, concepciones y prácticas psicológicas han cambiado a lo largo del tiempo, en conexión con las transformaciones socioculturales y políticas ocurridas durante el siglo XX. Para ello, se utilizaron las fuentes de investigación primarias y secundarias con miras a generar interpretaciones sobre las conexiones entre las ideas, los actores y los eventos narrados. Se argumenta, a lo largo de este artículo, que las ideas y las prácticas psicológicas están intrínsecamente conectadas a los contextos socioculturales y políticos de su tiempo, y los movimientos dinámicos y los conflictos presentes en estos contextos fueron los factores determinantes para su constitución.(AU)

Differences in Practice Characteristics Between Male and Female Chiropractors in South Africa: Secondary Analysis of Data From Scope of Practice Survey 2015.

OBJECTIVE: The aim of the study was to determine whether there were differences in practice characteristics between male and female chiropractors working in South Africa. METHODS: A secondary analysis of data from the online survey "The Analysis of the Scope of Chiropractic Practice in South Africa in 2015" was performed, relating to demographic data, work environment, patient data, chief complaint, treatment techniques, and conditions treated. The original survey yielded a 30% response rate (n = 214), of which 212 responses to the question relating to sex, indicated 56.13% (n = 119) male respondents and 43.87% (n = 93) female respondents. Using the X2 test, differences in practice characteristics between male and female chiropractors were compared. RESULTS: Significant differences were noted for South African female chiropractors reporting that they spent more time with patients during initial (P = .028) and subsequent (P = .0001) visits and more time on direct patient care (P = .0001). South African male chiropractors showed significant differences in being in practice for longer (P = .002), treating more patients per week (P = .0001), number of new patients seen per week (P = .0001), and spending more time working in their practice per week. CONCLUSION: We found differences between self-reported male and female chiropractors in their practice characteristics, particularly in the number of patients seen per week and hours worked per week. These factors may need to be considered in the profession as the number of female chiropractors increases.

Significados e representações do uso recreativo de maconha para mulheres / Meanings and representations of recreational use of marijuana by women

Diante das especificidades de gênero, este trabalho busca identificar o significado do uso recreativo de maconha para as mulheres em momentos de lazer. O estudo é uma pesquisa social desenvolvida por meio de entrevistas semiestruturadas. Foram entrevistadas 8 mulheres, acessadas pelo método 'Bola de Neve'. Resultados: Foram definidas as seguintes categorias de sentidos atribuídos ao uso da maconha pelas mulheres: sociabilidade, relacionamentos afetivos e sexo com uso da maconha; relaxamento e descanso; 'calmante' e medicamento; autoconhecimento, afirmação de identidade e criatividade. De acordo com os achados da pesquisa foi identificado que a maconha se insere no universo feminino como parte constituinte da cultura e da identidade das mulheres usuárias.

In view of gender specificities, this paper discusses the meaning of recreational use of marijuana by women at leisure. The study was a social survey was conducted through semi-structured interviews. Eight women were interviewed, they were accessed using the Snowball sampling method. Results: the data were systematized into categories of meanings attributed to the use of marijuana by women: sociability, affective relationships and sex with marijuana use; relaxation and rest; 'Soothing' and medicine; self-knowledge, identity affirmation and creativity. According to research findings, it was identified that marijuana is inserted in the female universe as a constituent part of the culture and identity of women.

CB1 receptors in corticotropin-releasing factor neurons selectively control the acoustic startle response in male mice.

The endocannabinoid system is an important regulator of the hormonal and behavioral stress responses, which critically involve corticotropin-releasing factor (CRF) and its receptors. While it has been shown that CRF and the cannabinoid type 1 (CB1) receptor are co-localized in several brain regions, the physiological relevance of this co-expression remains unclear. Using double in situ hybridization, we confirmed co-localization in the piriform cortex, the lateral hypothalamic area, the paraventricular nucleus, and the Barrington's nucleus, albeit at low levels. To study the behavioral and physiological implications of this co-expression, we generated a conditional knockout mouse line that selectively lacks the expression of CB1 receptors in CRF neurons. We found no effects on fear and anxiety-related behaviors under basal conditions nor after a traumatic experience. Additionally, plasma corticosterone levels were unaffected at baseline and after restraint stress. Only acoustic startle responses were significantly enhanced in male, but not female, knockout mice. Taken together, the consequences of depleting CB1 in CRF-positive neurons caused a confined hyperarousal phenotype in a sex-dependent manner. The current results suggest that the important interplay between the central endocannabinoid and CRF systems in regulating the organism's stress response is predominantly taking place at the level of CRF receptor-expressing neurons.

Educational Social Skills and Repertoire of Children Differentiated by Behavior and Sex / Habilidades Sociais Educativas e Repertório de Crianças Diferenciadas Por Comportamento e Sexo / Habilidades Sociales Educativas y Repertorio de Niños Diferenciados por Comportamiento y Sexo

Abstract Our study sought to compare mothers' behavioral repertoire (educational social skills and negative practices) and maternal anxiety and depression indicators with children's behaviors (behavior problems and social skills), by assessing the variables "sex" (boys and girls) and "occurrence of behavior problems". The sample consisted of 20 children with behavior problems (clinical group), 20 without behavior problems (non-clinical group), their mothers and teachers. Reporting instruments were used with teachers and mothers and comparative analyzes were conducted between groups. The results indicated that the clinical group had higher rates of behavior problems and maternal depressive symptoms, whereas the non-clinical group showed more child social and educational social skills. Sex did not differ between groups. We concluded that maternal educational practices are more influenced by children's behaviors than by their sex.

Resumo Este estudo objetivou comparar repertório comportamental de mães (habilidades sociais educativas e práticas negativas), indicadores de ansiedade e depressão maternos e comportamentos de crianças (problemas de comportamento e habilidades sociais), controlando as variáveis sexo (meninos e meninas) e ocorrência de problemas de comportamento. A amostra foi composta por 20 crianças com problemas de comportamento (grupo clínico), 20 sem problemas de comportamento (grupo não clínico), suas mães e professores. Foram utilizados instrumentos de relato com professores e mães e conduzidas análises comparativas entre os grupos. Os resultados indicaram que o grupo clínico apresentou maiores taxas em problemas de comportamento e sintomas de depressão materna, enquanto o grupo não clínico apresentou mais habilidades sociais infantis e habilidades sociais educativas. O sexo não diferenciou os grupos. Conclui-se que as práticas educativas maternas são mais influenciadas pelos comportamentos das crianças do que pelo sexo delas.

Resumen Este estudio tuvo como objetivo comparar el repertorio conductual de madres (habilidades sociales educativas y prácticas negativas), los indicadores de ansiedad y depresión maternos y los comportamientos de los niños (problemas del comportamiento y habilidades sociales) diferenciados por las variables sexo (niños y niñas) y la aparición de problemas del comportamiento. La muestra consistió en 20 niños con problemas del comportamiento (grupo clínico), 20 niños sin problemas del comportamiento (grupo no clínico), sus madres y maestros. Se utilizaron instrumentos de informe con maestros y madres y se realizaron análisis comparativos entre grupos. Los resultados indicaron que el grupo clínico tenía tasas más altas de problemas del comportamiento y síntomas de depresión materna, mientras que el grupo no clínico tenía más habilidades sociales infantiles y habilidades sociales educativas. El sexo no se diferenció en los grupos. Se concluye que las prácticas educativas maternas están más influenciadas por los comportamientos de los niños que por el sexo de los mismos.

Sex-specific phenotypes of histone H4 point mutants establish dosage compensation as the critical function of H4K16 acetylation in Drosophila.

Acetylation of histone H4 at lysine 16 (H4K16) modulates nucleosome-nucleosome interactions and directly affects nucleosome binding by certain proteins. In Drosophila, H4K16 acetylation by the dosage compensation complex subunit Mof is linked to increased transcription of genes on the single X chromosome in males. Here, we analyzed Drosophila containing different H4K16 mutations or lacking Mof protein. An H4K16A mutation causes embryonic lethality in both sexes, whereas an H4K16R mutation permits females to develop into adults but causes lethality in males. The acetyl-mimic mutation H4K16Q permits both females and males to develop into adults. Complementary analyses reveal that males lacking maternally deposited and zygotically expressed Mof protein arrest development during gastrulation, whereas females of the same genotype develop into adults. Together, this demonstrates the causative role of H4K16 acetylation by Mof for dosage compensation in Drosophila and uncovers a previously unrecognized requirement for this process already during the onset of zygotic gene transcription.

Sex differences impact the lung-bone inflammatory response to repetitive inhalant lipopolysaccharide exposures in mice.

Skeletal health consequences associated with inflammatory diseases of the airways significantly contribute to morbidity. Sex differences have been described independently for lung and bone diseases. Repetitive inhalant exposure to lipopolysaccharide (LPS) induces bone loss and deterioration in male mice, but comparison effects in females are unknown. Using an intranasal inhalation exposure model, 8-week-old C57BL/6 male and female mice were treated daily with LPS (100 ng) or saline for 3 weeks. Bronchoalveolar lavage fluids, lung tissues, tibias, bone marrow cells, and blood were collected. LPS-induced airway neutrophil influx, interleukin (IL)-6 and neutrophil chemoattractant levels, and bronchiolar inflammation were exaggerated in male animals as compared to female mice. Trabecular bone micro-CT imaging and analysis of the proximal tibia were conducted. Inhalant LPS exposures lead to deterioration of bone quality only in male mice (not females) marked by decreased bone mineral density, bone volume/tissue volume ratio, trabecular thickness and number, and increased bone surface-to-bone volume ratio. Serum pentraxin-2 levels were modulated by sex differences and LPS exposure. In proof-of-concept studies, ovarectomized female mice demonstrated LPS-induced bone deterioration, and estradiol supplementation of ovarectomized female mice and control male mice protected against LPS-induced bone deterioration findings. Collectively, sex-specific differences exist in LPS-induced airway inflammatory consequences with significant differences found in bone quantity and quality parameters. Male mice demonstrated susceptibility to bone loss and female animals were protected, which was modulated by estrogen. Therefore, sex differences influence the biologic response in the lung-bone inflammatory axis in response to inhalant LPS exposures.

Relatório Semestral 2016 Relatório Semestral das Actividades Relacionadas ao HIV/SIDA / Semestral Report 2016 Mid-Year Report on Activities Related to HIV/AIDS

O Programa Nacional de Controlo (PNC) de ITS-HIV/SIDA é a entidade do Serviço Nacional de Saúde responsável pela gestão dos serviços de saúde relacionados ao HIV. A sua missão é de coordenar, regulamentar e prestar cuidados e tratamento às pessoas vivendo com HIV. Para responder de forma estratégica aos desafios desta missão, o PNC ITS-HIV/SIDA conta com as seguintes componentes sendo: 1) Cuidados Clínicos e TARV Adulto; 2) Cuidados Clínicos e TARV Pediátrico; 3) TB/HIV; 4) APSS/PP; 5) ITS; 6) ATS; 7) Monitoria e Avaliação e 8) Melhoria de Qualidade. No primeiro semestre de 2016, o Programa de ITS-HIV/SIDA deu continuidade as actividades anteriormente traçadas nos planos vigentes e comprometeu-se a alcançar as ambiciosas metas, apesar dos desafios encontrados ao longo da implementação. Referir que estas actividades concorrem para uma melhoria na qualidade de vida dos Moçambicanos...

The National Control Program (NCP) for STI-HIV/AIDS is the National Health Service entity responsible for managing HIV-related health services. Its mission is to coordinate, regulate, and provide care and treatment for people living with HIV. To respond in a strategic strategic response to the challenges of this mission, the NHP STI-HIV/AIDS has the following components being: 1) Adult Clinical Care and ART; 2) Pediatric Clinical Care and ART; 3) TB/HIV; 4) APSS/PP; 5) ITS; 6) ATS; 7) Monitoring and Evaluation and 8) Quality Improvement. In the first half of 2016, the STI-HIV/AIDS Program continued the activities previously outlined in the current plans and committed to achieving the ambitious targets, despite the challenges encountered throughout implementation. It should be noted that these activities contribute to an improvement in the quality of life of Mozambicans...

Factors that contribute to the willingness to try "street hypnosis".

This study takes a context-specific approach to examine people's willingness to try hypnosis under various conditions and the factors that contribute to their willingness. It examined 378 participants, who completed a web-based hypnosis survey. The results showed that people's willingness to try hypnosis varies by context. Specifically, people are more willing to try hypnosis when it is framed as "peak focus" rather than "hypnosis" and when they perceive the environment as being safer. Moreover, factors including participants' demographics, hypnotists' demographics (relative to the subjects'), participants' control bias, and knowledge of hypnosis affect people's degrees of willingness to try hypnosis, depending on the specific context. The results suggest further analysis of hypnosis occurring in public contexts and the effects it may have on attitudes and therapeutic outcomes.

Actitudes hacia las mujeres de los esquemáticos frente a los no esquemáticos de género / Attitude towards women of gender schematic vs aschematic individuals

Tras la cuádruple tipología de género (década de los setenta), un nuevo modelo dual surgió en los ochenta: personas con esquema de género frente a las no esquemáticas. En el presente trabajo se examina la relación entre estas categorías y las actitudes hacia las mujeres, utilizando el Bem Sex Role Inventory y Attitudes Towards Women Scale. Se llevaron a cabo dos estudios con adolescentes (chicos y chicas) de 12 a 14 años: el primero (2001) con 359 participantes y el de réplica (2009) con 224. Se realizaron análisis factoriales y ANOVAS. Los resultados, de ambos estudios, apoyan la hipótesis de que las adolescentes muestran una actitud más favorable que los adolescentes hacia las mujeres. Las personas femeninas o andróginas respondieron de forma semejante, pero de modo diferente al resto. Los varones masculinos y las mujeres femeninas no mostraron diferencias en las actitudes hacia las mujeres frente a las personas sin esquema de género o de género cruzado. Respecto a las posibles diferencias entre los esquemáticos típicos frente a los atípicos y las de los esquemáticos frente a los indiferenciados, los resultados son discrepantes. Se establecen las implicaciones tanto para los instrumentos utilizados como para las teorías subyacentes (AU)

After the fourfold gender typology (1970s), a dual model -gender schematic versus aschematic individuals- emerged in the 1980s. In this research, the relationship between gender schemas and attitudes towards women’s rights were tested. Two studies were carried out (2001 and 2009) with adolescents (boys and girls) from 12 to 14 years old, with 359 participants in 2001 and 224 in 2009, using two instruments: the Bem Sex Role Inventory and the Attitudes Towards Women Scale. Factor analysis and ANOVAs were carried out. The results of both studies supported the hypothesis that girls maintain more favourable attitudes about themselves than boys do. Both studies supported the hypothesis that feminine and androgynous individuals display similar attitudes towards women, but they differ from the other gender categories. Masculine boys and feminine girls did not show differences in attitudes towards women in comparison to aschematic or cross-gendered adolescents. Inconsistent results were found between studies regarding the hypothesized differences between typical and atypical schematics in attitudes towards women, as well as between undifferentiated and gender schematic individuals. The implications of these results for the instruments used, as well as for theories, are considered (AU)

Relationships between tree size, crown shape, gender segregation and sex allocation in Pinus halepensis, a Mediterranean pine tree.

BACKGROUND AND AIMS: Sex allocation has been studied mainly in small herbaceous plants but much less in monoecious wind-pollinated trees. The aim of this study was to explore changes in gender segregation and sex allocation by Pinus halepensis, a Mediterranean lowland pine tree, within tree crowns and between trees differing in their size or crown shape. METHODS: The production of new male and female cones and sex allocation of biomass, nitrogen and phosphorus were studied. The relationship between branch location, its reproductive status and proxies of branch vigour was also studied. KEY RESULTS: Small trees produced only female cones, but, as trees grew, they produced both male and female cones. Female cones were produced mainly in the upper part of the crown, and male cones in its middle and lower parts. Lateral branch density was correlated with the number of male but not female cones; lateral branches were more dense in large than in small trees and even denser in hemispherical trees. Apical branches grew faster, were thicker and their phosphorus concentration was higher than in lateral shoots. Nitrogen concentration was higher in cone-bearing apical branches than in apical vegetative branches and in lateral branches with or without cones. Allocation to male relative to female function increased with tree size as predicted by sex allocation theory. CONCLUSIONS: The adaptive values of sex allocation and gender segregation patterns in P. halepensis, in relation to its unique life history, are demonstrated and discussed. Small trees produce only female cones that have a higher probability of being pollinated than the probability of male cones pollinating; the female-first strategy enhances population spread. Hemispherical old trees are loaded with serotinous cones that supply enough seeds for post-fire germination; thus, allocation to males is more beneficial than to females.

Carotenoid supplementation and sex-specific trade-offs between colouration and condition in common tern chicks.

Carotenoids, as pigments with antioxidant and immunoregulatory properties, play a crucial role in developing chicks. Carotenoids must be acquired through diet and are relatively scarce, suggesting that their availability is a limiting factor leading to a trade-off between colour displays and physiological functions. However, potential differences in this trade-off between male and female chicks have been little studied. We manipulated carotenoid availability in 9 days old common tern Sterna hirundo chicks by supplementing their fish diet with four carotenoids during 9 days. Our aim was to examine sex-specific responses to the experimental increase of dietary carotenoids on plasma circulation, physiological and condition variables and successful fledging. Furthermore, to explore the functional and evolutionary basis of the trade-off, we studied the relationships among carotenoid concentration, mediated immune response and foot colouration. After treatment, control chicks showed decreasing plasma levels for most carotenoid types, whereas supplemented chicks had strong increases. Colour luminosity and saturation increased in both treatment groups, while hue only changed significantly towards redder feet in supplemented females. Supplemented chicks presented neither different T-cell-mediated immunity nor other differences compared to control chicks. Nevertheless, supplemented females showed tendencies towards decreased immune responses and increased δ(15)N signatures, and supplemented males towards greater body mass. Our results indicate colouration may have, in females, a signalling function as to compensate for immunological costs. In males, additional availability of carotenoids may contribute to improve the body condition. This study suggests that trade-off responses to carotenoid availability are sex-specific in tern chicks. Thus, parental carotenoid supply to chicks may be an unrecognised component in sex allocation.

Spatial seed and pollen games: dispersal, sex allocation, and the evolution of dioecy.

The evolutionary forces shaping within- and across-species variation in the investment in male and female sex function are still incompletely understood. Despite earlier suggestions that in plants the evolution or cosexuality vs. dioecy, as well as sex allocation among cosexuals, is affected by seed and pollen dispersal, no formal model has explicitly used dispersal distances to address this problem. Here, we present a game-theory model as well as a simulation study that fills in this gap. Our model predicts that dioecy should evolve if seeds and pollen disperse widely and that sex allocation among cosexuals should be biased towards whichever sex function produces more widely dispersing units. Dispersal limitations stabilize cosexuality by reinforcing competition between spatially clumped dispersal units from the same source, leading to saturating fitness returns that render sexual specialization unprofitable. However, limited pollen dispersal can also increase the risk of selfing, thus potentially selecting for dioecy as an outbreeding mechanism. Finally, we refute a recent claim that cosexuals should always invest equally in both sex functions.

Ideas clave para desarrollar educación para la salud sobre afectividad y sexualidad. Educando para la vida / No disponible

Este artículo muestra ideas clave para incluir en los contenidos de los programas de educación para la salud sobre afectividad y sexualidad, normalmente dirigidos a adolescentes, pero que también tienen una acogida excelente entre los adultos. Actualmente se plantea una reflexión importante más allá de la idea clásica de educar para evitar embarazos no deseados y enfermedades de transmisión sexual: el sexo es una fuerza positiva y enriquecedora de la vida humana que contribuye a nuestro proceso de crecimiento personal como seres completos (cuerpo + energía + emociones + mente + alma). Es la salud sexual desde el punto de vista holístico (total), la salud como máximo desarrollo de la persona (AU)

This article shows key ideas to include in the contents of the programs of health education on affectivity and sexuality, normally directed to teenagers, but that also have an excellent reception among the adults. Nowadays an important reflection appears beyond the classic idea of educating to avoid not wished pregnancies and diseases of sexual transmission: sex is a positive and enriching force of human life that contributes to our process of personal growth as complete beings (body + energy + emotions + mind + soul). It is the sexual health from the holistic (total) point of view, health as the greatest development of the person (AU)

Brain potentials to sexually suggestive whistles show meaning modulates the mismatch negativity.

Electroencephalographic data suggest that spoken words produce an enhanced output of the brain's automatic deviance detection system, as reflected by the mismatch negativity. Using meaningful and nonmeaningful whistles, we sought to distinguish the effect of semantic content on the brain's deviance detection system from language-specific stimulus features. In the meaningful condition, study participants heard a human 'wolf whistle', which is commonly interpreted as an unsolicited expression of sexual attention. In the nonmeaningful condition participants heard an acoustically identical, but digitally rearranged, version of the wolf whistle. The mismatch negativity amplitude was significantly larger when the infrequent stimulus was meaningful than when it was meaningless. These data suggest that enhanced mismatch negativity magnitude was due to the semantic valence of the eliciting deviant.

Androgens up-regulate atherosclerosis-related genes in macrophages from males but not females: molecular insights into gender differences in atherosclerosis.

OBJECTIVES: This study investigated the effects of androgens on gene expression in male- and female-donor macrophages. BACKGROUND: Men have more severe coronary disease than women. Androgen exposure increases foam cell formation in male but not female macrophages, and male macrophages express >4-fold more androgen receptor messenger ribonucleic acid than female macrophages. Therefore, androgen exposure may have gender-specific and potentially pro-atherogenic effects in macrophages. METHODS: Utilizing complementary deoxyribonucleic acid arrays, we studied the effects of a pure androgen (dihydrotestosterone, 40 nmol/l) on human monocyte-derived macrophages from healthy male and female donors (n = 4 hybridizations; 2 men, 2 women). Differential expression of atherosclerosis-related genes was confirmed by real-time reverse transcription-polymerase chain reaction (RT-PCR) in five male and five female donors. Functional corroboration of foam cell formation-related findings was undertaken by experiments using (125)I-acetylated low-density lipoprotein (AcLDL). RESULTS: In male macrophages, androgen treatment produced differential up-regulation of 27 genes concentrated in five functional classes: 1) lipoprotein processing; 2) cell-surface adhesion; 3) extracellular signaling; 4) coagulation and fibrinolysis; and 5) transport protein genes. By contrast, none of 588 genes were up-regulated in female macrophages. By RT-PCR, we confirmed the gender-specific up-regulation of six of these atherosclerosis-related genes: acyl coenzyme A:cholesterol acyl transferase I, lysosomal acid lipase (LAL), caveolin-2, CD40, vascular endothelial growth factor-165 receptor, and tissue factor pathway inhibitor. Functionally, androgen-treated male macrophages showed increased rates of lysosomal AcLDL degradation, by 45% to 75% after 15 to 20 h of (125)I-AcLDL incubation (p = 0.001), consistent with increased LAL activity. CONCLUSIONS: Androgens increase expression of atherosclerosis-related genes in male but not female macrophages, with functional consequences. These findings may contribute to the male predisposition to atherosclerosis.